Passive Immunization with Anti-Glucosaminidase Monoclonal Antibodies Protects Mice from Implant-Associated Osteomyelitis by Mediating Opsonophagocytosis of Staphylococcus aureus Megaclusters

Towards development of a methicillin-resistant S. aureus (MRSA) vaccine we evaluated a neutralizing anti-glucosaminidase (Gmd) monoclonal antibody (1C11) in a murine model of implant-associated osteomyelitis, and compared its effects on LAC USA300 MRSA versus placebo (alpha-T2m) and a Gmd-deficient...

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Pubblicato in:J Orthop Res
Autori principali: Varrone, John J., de Mesy Bentley, Karen L., Bello-Irizarry, Sheila N., Nishitani, Kohei, Mack, Sarah, Hunter, Joshua G., Kates, Stephen L., Daiss, John L., Schwarz, Edward M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234088/
https://ncbi.nlm.nih.gov/pubmed/24992290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.22672
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