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Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action

In this article, we first review current knowledge of the AMPA and NMDA glutamate receptors, their physiological properties and functions and their regulation by signaling cascades. We then discuss our hypothesis that the therapeutic effects of monoaminergic antidepressants and ketamine, an NMDA rec...

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Detalles Bibliográficos
Publicado en:Drug Discov Today Ther Strateg
Main Authors: Du, Jing, Machado-Vieira, Rodrigo, Maeng, Sungho, Martinowich, Keri, Manji, Husseini K., Zarate, Carlos A.
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234070/
https://ncbi.nlm.nih.gov/pubmed/25411578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddstr.2006.11.012
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