Alpha-1-antitrypsin-Pittsburgh. A potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf.

Alpha-1-antitrypsin-Pittsburgh is a human variant that resulted from a point mutation in the plasma protease inhibitor, alpha 1-antitrypsin (358 Met----Arg). This defect in the alpha 1-antitrypsin molecule causes it to have greatly diminished anti-elastase activity but markedly increased antithrombi...

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Pubblicato in:	J Clin Invest
Autori principali:	Scott, C F, Carrell, R W, Glaser, C B, Kueppers, F, Lewis, J H, Colman, R W
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423401/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3484755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112346
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