Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation

Sphingosine 1-phosphate (S1P) is a powerful regulator of platelet formation. Enzymes generating S1P include sphingosine kinase 1. The present study thus explored the role of sphingosine kinase 1 in platelet formation and function. Activation-dependent platelet integrin α(IIb)β(3) activation and secr...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Münzer, Patrick, Schmid, Evi, Walker, Britta, Fotinos, Anna, Chatterjee, Madhumita, Rath, Dominik, Vogel, Sebastian, Hoffmann, Sascha M., Metzger, Katja, Seizer, Peter, Geisler, Tobias, Gawaz, Meinrad, Borst, Oliver, Lang, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233262/
https://ncbi.nlm.nih.gov/pubmed/25231106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00029.2014
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