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Mechanisms of NFATc3 activation by increased superoxide and reduced hydrogen peroxide in pulmonary arterial smooth muscle

We recently demonstrated increased superoxide (O(2)(·−)) and decreased H(2)O(2) levels in pulmonary arteries of chronic hypoxia-exposed wild-type and normoxic superoxide dismutase 1 (SOD1) knockout mice. We also showed that this reciprocal change in O(2)(·−) and H(2)O(2) is associated with elevated...

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Bibliographic Details
Published in:Am J Physiol Cell Physiol
Main Authors: Ramiro-Diaz, Juan Manuel, Giermakowska, Wieslawa, Weaver, John M., Jernigan, Nikki L., Gonzalez Bosc, Laura V.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233259/
https://ncbi.nlm.nih.gov/pubmed/25163518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00244.2014
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