Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically-induced Skin Cancer

Pharmacologic and global gene deletion studies demonstrate that cyclooxygenase-2 (PTGS2/COX2) plays a critical role in DMBA/TPA-induced skin tumor induction. While many cell types in the tumor microenvironment express COX-2, the cell types in which COX-2 expression is required for tumor promotion ar...

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Publicado en:Mol Cancer Res
Main Authors: Jiao, Jing, Ishikawa, Tomo-o, Dumlao, Darren S., Norris, Paul C., Magyar, Clara E., Mikulec, Carol, Catapang, Art, Dennis, Edward A., Fischer, Susan M., Herschman, Harvey R.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233191/
https://ncbi.nlm.nih.gov/pubmed/25063587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0397-T
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