In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer

Bladder cancer (BC) is a highly prevalent human disease in which retinoblastoma (Rb) pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Retinoblastoma (Rb...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Santos, Mirentxu, Martínez-Fernández, Mónica, Dueñas, Marta, García-Escudero, Ramón, Alfaya, Begoña, Villacampa, Felipe, Saiz-Ladera, Cristina, Costa, Clotilde, Oteo, Marta, Duarte, José, Martínez, Victor, Gómez-Rodriguez, Mª José, Martín, Mª Luisa, Fernández, Manoli, Viatour, Patrick, Morcillo, Miguel A, Sage, Julien, Castellano, Daniel, Rodriguez-Peralto, Jose L, de la Rosa, Federico, Paramio, Jesús M
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233185/
https://ncbi.nlm.nih.gov/pubmed/25252918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1218
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