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Selective Inhibition of rDNA Transcription by a Small-Molecule Peptide that Targets the Interface Between RNA Polymerase I and Rrn3

The interface between the polymerase I associated factor Rrn3 and the 43 kDa subunit of RNA polymerase I is essential to the recruitment of Pol I to the preinitiation complex on the rDNA promoter. In silico analysis identified an evolutionarily conserved 22 amino acid peptide within rpa43 that is bo...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Rothblum, Katrina, Hu, Qiyue, Penrod, Yvonne, Rothblum, Lawrence I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233170/
https://ncbi.nlm.nih.gov/pubmed/25033839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0229
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