STAT3 Induction of MiR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes

Interleukin-6 (IL-6)-mediated activation of signal transducer and activator of transcription 3 (STAT3) is a mechanism by which chronic inflammation can contribute to cancer and is a common oncogenic event. We discovered a pathway the loss of which is associated with persistent STAT3 activation in hu...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Xiang, Michael, Birkbak, Nicolai J., Vafaizadeh, Vida, Walker, Sarah R., Yeh, Jennifer E., Liu, Suhu, Kroll, Yasmin, Boldin, Mark, Taganov, Konstantin, Groner, Bernd, Richardson, Andrea L., Frank, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233120/
https://ncbi.nlm.nih.gov/pubmed/24473196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004497
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