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NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies
MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-κB activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107319/ https://ncbi.nlm.nih.gov/pubmed/21576471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105398108 |
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