NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies

MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-κB activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhao, Jimmy L., Rao, Dinesh S., Boldin, Mark P., Taganov, Konstantin D., O'Connell, Ryan M., Baltimore, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107319/
https://ncbi.nlm.nih.gov/pubmed/21576471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105398108
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