Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination

We have assessed the immune-regulatory and adjuvant activities of a synthetic glycolipid, ABX196, a novel analog of the parental compound α-GalCer. As expected, ABX196 demonstrated a measurable and significant adjuvant effect in mice and monkeys with no appreciable toxicity at the doses used to prom...

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Udgivet i:Vaccine
Main Authors: Tefit, Josianne Nitcheu, Crabé, Sandrine, Orlandini, Bernard, Nell, Haylene, Bendelac, Albert, Deng, Shenglou, Savage, Paul B., Teyton, Luc, Serra, Vincent
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233108/
https://ncbi.nlm.nih.gov/pubmed/25218293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.08.070
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