A new histone deacetylase inhibitor improves liverfibrosis in BDL rats through suppression of hepatic stellate cells

BACKGROUND AND PURPOSE: Activation of hepatic stellate cells (HSCs) is a crucial step in the pathogenesis of hepatic fibrosis. Histone deacetylase (HDAC) is an attractive target in liver fibrosis because it plays a key role in gene expression and cell differentiation. We have developed a HDAC inhibi...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Park, Ki Cheong, Park, Ji Hyun, Jeon, Jeong Yong, Kim, Sang Yong, Kim, Jung Min, Lim, Chang Yong, Lee, Tae Hyung, Kim, Hyung Kwan, Lee, Hyun Gyu, Kim, Sung Min, Kwon, Ho Jeong, Suh, Jin Suck, Kim, Seung Won, Choi, Seung Hoon
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232907/
https://ncbi.nlm.nih.gov/pubmed/24467283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12590
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