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Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation
The ribosomal protein L11 binds to and suppresses the E3 ligase function of HDM2, thus activating p53. Despite being abundant as a component of the 60S large ribosomal subunit, L11 does not induce p53 under normal growth conditions. In search of mechanisms controlling L11–HDM2 interaction, we found...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC423289/ https://ncbi.nlm.nih.gov/pubmed/15152193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600247 |
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