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Total Synthesis of the Anti-inflammatory and Pro-resolving Lipid Mediator MaR1(n-3 DPA) Utilizing an sp(3)-sp(3) Negishi Cross-coupling Reaction()
The first total synthesis of the lipid mediator MaR1(n-3 DPA) (5) has been achieved in 12% overall yield over 11 steps. The stereoselective preparation of 5 was based on a Pd-catalyzed sp(3)-sp(3) Negishi cross-coupling reaction and a stereo controlled Evans-Nagao acetate aldol reaction. LC-MS/MS re...
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| Publicado no: | Chemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4232850/ https://ncbi.nlm.nih.gov/pubmed/25225129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201404721 |
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