The Supraspliceosome — A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus

Pre-mRNA splicing of Pol II transcripts is executed in the mammalian cell nucleus within a huge (21 MDa) and highly dynamic RNP machine — the supraspliceosome. It is composed of four splicing active native spliceosomes, each resembling an in vitro assembled spliceosome, which are connected by the pr...

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Bibliografiske detaljer
Udgivet i:Comput Struct Biotechnol J
Main Authors: Shefer, Kinneret, Sperling, Joseph, Sperling, Ruth
Format: Artigo
Sprog:Inglês
Udgivet: Research Network of Computational and Structural Biotechnology 2014
Fag:
Mini Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232567/
https://ncbi.nlm.nih.gov/pubmed/25408845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2014.09.008
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