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Primary Murine CD4(+) T Cells Fail to Acquire the Ability to Produce Effector Cytokines When Active Ras Is Present during Th1/Th2 Differentiation
Constitutive Ras signaling has been shown to augment IL-2 production, reverse anergy, and functionally replace many aspects of CD28 co-stimulation in CD4(+) T cells. These data raise the possibility that introduction of active Ras into primary T cells might result in improved functionality in pathol...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4232516/ https://ncbi.nlm.nih.gov/pubmed/25397617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112831 |
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