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Spatial encoding of cyclic AMP signalling specificity by GPCR endocytosis

G protein-coupled receptors (GPCRs) are well known to signal via cyclic AMP (cAMP) production at the plasma membrane, but it is now clear that various GPCRs also signal after internalization. Apart from its temporal impact through prolonging the cellular response, does the endosome-initiated signal...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Tsvetanova, Nikoleta G., von Zastrow, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232470/
https://ncbi.nlm.nih.gov/pubmed/25362359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1665
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