The linker-loop region of Escherichia coli chaperone Hsp31 functions as a gate that modulates high-affinity substrate binding at elevated temperatures

Precise control of substrate binding and release is essential for molecular chaperones to exert their protective function in times of stress. The mechanisms used are diverse and have been difficult to unravel. Escherichia coli heat-shock protein 31 (Hsp31) is a recent addition to the known complemen...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sastry, M. S. R., Quigley, Paulene M., Hol, Wim G. J., Baneyx, François
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423238/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15173574/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403033101
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