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Small-Molecule Antagonists for CXCR2 and CXCR1 Inhibit Human Melanoma Growth by Decreasing Tumor Cell Proliferation, Survival, and Angiogenesis

PURPOSE: Melanoma, the most aggressive form of skin cancer, accounts for 75% of all skin cancer-related deaths and current therapeutic strategies are not effective in advanced disease. In the current study, we have investigated the efficacy of orally active small-molecule antagonist targeting CXCR2/...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Singh, Seema, Sadanandam, Anguraj, Nannuru, Kalyan C., Varney, Michelle L., Mayer-Ezell, Rosemary, Bond, Richard, Singh, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232212/
https://ncbi.nlm.nih.gov/pubmed/19293256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2387
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