Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone

The thiazolidinedione class peroxisome proliferator-activated receptor gamma (PPARγ) agonists are restricted in clinical use as antidiabetic agents because of side effects such as edema, weight gain, and heart failure. The single and selective agonism of PPARγ is the main cause of these side effects...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Wang, Xue-Jiao, Zhang, Jun, Wang, Shu-Qing, Xu, Wei-Ren, Cheng, Xian-Chao, Wang, Run-Ling
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2014
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232041/
https://ncbi.nlm.nih.gov/pubmed/25422585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S70383
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