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Epigenetic Modifications of Keap1 Regulate Its Interaction With the Protective Factor Nrf2 in the Development of Diabetic Retinopathy
PURPOSE. Diabetes induces oxidative imbalance in the retina and impairs Nrf2-mediated antioxidant response, and elevates Keap1, the cytoplasmic repressor of Nrf2. The goal of this study was to understand the role of epigenetic modifications at Keap1 promoter in regulation of Nrf2 function. METHODS....
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| Udgivet i: | Invest Ophthalmol Vis Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Association for Research in Vision and Ophthalmology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4231994/ https://ncbi.nlm.nih.gov/pubmed/25301875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-15193 |
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