Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling throu...

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Detalhes bibliográficos
Main Authors: Sansom, Owen J., Reed, Karen R., Hayes, Anthony J., Ireland, Heather, Brinkmann, Hannah, Newton, Ian P., Batlle, Eduard, Simon-Assmann, Patricia, Clevers, Hans, Nathke, Inke S., Clarke, Alan R., Winton, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC423189/
https://ncbi.nlm.nih.gov/pubmed/15198980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.287404
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