A Direct Interaction between the Sigma-1 Receptor and the hERG Voltage-gated K(+) Channel Revealed by Atomic Force Microscopy and Homogeneous Time-resolved Fluorescence (HTRF®)

The sigma-1 receptor is an endoplasmic reticulum chaperone protein, widely expressed in central and peripheral tissues, which can translocate to the plasma membrane and modulate the function of various ion channels. The human ether-à-go-go-related gene encodes hERG, a cardiac voltage-gated K(+) chan...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Balasuriya, Dilshan, D'Sa, Lauren, Talker, Ronel, Dupuis, Elodie, Maurin, Fabrice, Martin, Patrick, Borgese, Franck, Soriani, Olivier, Edwardson, J. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231707/
https://ncbi.nlm.nih.gov/pubmed/25266722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.603506
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