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The Reductive Half-reaction of Xanthine Dehydrogenase from Rhodobacter capsulatus: THE ROLE OF GLU(232) IN CATALYSIS

The kinetic properties of an E232Q variant of the xanthine dehydrogenase from Rhodobacter capsulatus have been examined to ascertain whether Glu(232) in wild-type enzyme is protonated or unprotonated in the course of catalysis at neutral pH. We find that k(red), the limiting rate constant for reduct...

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Publicat a:J Biol Chem
Autors principals: Hall, James, Reschke, Stefan, Cao, Hongnan, Leimkühler, Silke, Hille, Russ
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231688/
https://ncbi.nlm.nih.gov/pubmed/25258317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.603456
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