Molecular Basis Determining Inhibition/Activation of Nociceptive Receptor TRPA1 Protein: A SINGLE AMINO ACID DICTATES SPECIES-SPECIFIC ACTIONS OF THE MOST POTENT MAMMALIAN TRPA1 ANTAGONIST

The transient receptor potential ankyrin 1 (TRPA1) is a Ca(2+)-permeable, nonselective cation channel mainly expressed in a subset of nociceptive neurons. TRPA1 functions as a cellular sensor detecting mechanical, chemical, and thermal stimuli. Because TRPA1 is considered to be a key player in nocic...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Banzawa, Nagako, Saito, Shigeru, Imagawa, Toshiaki, Kashio, Makiko, Takahashi, Kenji, Tominaga, Makoto, Ohta, Toshio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231671/
https://ncbi.nlm.nih.gov/pubmed/25271161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586891
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