New Selective Peptidyl Di(chlorophenyl) Phosphonate Esters for Visualizing and Blocking Neutrophil Proteinase 3 in Human Diseases

The function of neutrophil protease 3 (PR3) is poorly understood despite of its role in autoimmune vasculitides and its possible involvement in cell apoptosis. This makes it different from its structural homologue neutrophil elastase (HNE). Endogenous inhibitors of human neutrophil serine proteases...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Guarino, Carla, Legowska, Monika, Epinette, Christophe, Kellenberger, Christine, Dallet-Choisy, Sandrine, Sieńczyk, Marcin, Gabant, Guillaume, Cadene, Martine, Zoidakis, Jérôme, Vlahou, Antonia, Wysocka, Magdalena, Marchand-Adam, Sylvain, Jenne, Dieter E., Lesner, Adam, Gauthier, Francis, Korkmaz, Brice
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231656/
https://ncbi.nlm.nih.gov/pubmed/25288799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591339
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