P2Y(6) receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells

The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and modulates the progression of chronic inflammatory disease through activation of the receptor CCR2. Here, we show that co-activation of the P2Y(6) purinergic receptor (encoded...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Sci
Prif Awduron: Campwala, Hinnah, Sexton, Darren W., Crossman, David C., Fountain, Samuel J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231309/
https://ncbi.nlm.nih.gov/pubmed/25271060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.159012
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