P2Y(6) receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells

The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and modulates the progression of chronic inflammatory disease through activation of the receptor CCR2. Here, we show that co-activation of the P2Y(6) purinergic receptor (encoded...

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Udgivet i:J Cell Sci
Main Authors: Campwala, Hinnah, Sexton, Darren W., Crossman, David C., Fountain, Samuel J.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231309/
https://ncbi.nlm.nih.gov/pubmed/25271060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.159012
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