A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K/AKT pathway mutations

Rhabdomyosarcoma (RMS), a cancer of skeletal muscle lineage, is the most common soft-tissue sarcoma in children [1]. Major subtypes of RMS include alveolar (ARMS) and embryonal (ERMS).[2, 3] Whereas ARMS typically contain translocations generating the PAX3-FOXO1 or PAX7-FOXO1 aberrant transcription...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Kohsaka, Shinji, Shukla, Neerav, Ameur, Nabahet, Ito, Tatsuo, Ng, Charlotte K.Y., Wang, Lu, Lim, Diana, Marchetti, Angela, Viale, Agnes, Pirun, Mono, Socci, Nicholas D., Qin, Li-Xuan, Sciot, Raf, Bridge, Julia, Singer, Samuel, Meyers, Paul, Wexler, Leonard H., Barr, Frederic G., Dogan, Snjezana, Fletcher, Jonathan A., Reis-Filho, Jorge S., Ladanyi, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231202/
https://ncbi.nlm.nih.gov/pubmed/24793135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2969
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