TBL2 Is a Novel PERK-Binding Protein that Modulates Stress-Signaling and Cell Survival during Endoplasmic Reticulum Stress

Under ER stress, PKR-like ER-resident kinase (PERK) phosphorylates translation initiation factor eIF2α, resulting in repression of global protein synthesis and concomitant upregulation of the translation of specific mRNAs such as activating transcription factor 4 (ATF4). This PERK function is import...

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Veröffentlicht in:PLoS One
Hauptverfasser: Tsukumo, Yoshinori, Tsukahara, Satomi, Furuno, Aki, Iemura, Shun-ichiro, Natsume, Toru, Tomida, Akihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231078/
https://ncbi.nlm.nih.gov/pubmed/25393282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112761
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