In Vivo Experiments Reveal the Good, the Bad and the Ugly Faces of sFlt-1 in Pregnancy

OBJECTIVE: Soluble fms-like tyrosine kinase (sFlt)-1-e15a, a primate-specific sFlt-1-isoform most abundant in the human placenta in preeclampsia, can induce preeclampsia in mice. This study compared the effects of full-length human (h)sFlt-1-e15a with those of truncated mouse (m)sFlt-1(1-3) used in...

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Pubblicato in:PLoS One
Autori principali: Szalai, Gabor, Xu, Yi, Romero, Roberto, Chaiworapongsa, Tinnakorn, Xu, Zhonghui, Chiang, Po Jen, Ahn, Hyunyoung, Sundell, Birgitta, Plazyo, Olesya, Jiang, Yang, Olive, Mary, Wang, Bing, Jacques, Suzanne M., Qureshi, Faisal, Tarca, Adi L., Erez, Offer, Dong, Zhong, Papp, Zoltan, Hassan, Sonia S., Hernandez-Andrade, Edgar, Than, Nandor Gabor
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230935/
https://ncbi.nlm.nih.gov/pubmed/25393290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110867
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