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Latency of transcription factor Stp1 depends on a modular regulatory motif that functions as cytoplasmic retention determinant and nuclear degron

The Ssy1-Ptr3-Ssy5 (SPS)–sensing pathway enables yeast to respond to extracellular amino acids. Stp1, the effector transcription factor, is synthesized as a latent cytoplasmic precursor with an N-terminal regulatory domain that restricts its nuclear accumulation. The negative regulatory mechanisms i...

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Bibliografiske detaljer
Udgivet i:Mol Biol Cell
Main Authors: Omnus, Deike J., Ljungdahl, Per O.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230787/
https://ncbi.nlm.nih.gov/pubmed/25253722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-06-1140
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