Increase in cytosolic Ca(2+) produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body

The current model of O(2) sensing by carotid body chemoreceptor (glomus) cells is that hypoxia inhibits the outward K(+) current and causes cell depolarization, Ca(2+) influx via voltage-dependent Ca(2+) channels and a rise in intracellular [Ca(2+)] ([Ca(2+)](i)). Here we show that hypoxia (<5% O...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Physiol
Prif Awduron: Kang, Dawon, Wang, Jiaju, Hogan, James O, Vennekens, Rudi, Freichel, Marc, White, Carl, Kim, Donghee
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BlackWell Publishing Ltd 2014
Pynciau:
Respiratory
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230773/
https://ncbi.nlm.nih.gov/pubmed/24591572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.266957
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