Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca(2+) release

Phosphorylation of the cardiac ryanodine receptor (RyR2) by protein kinase A (PKA) at Ser-2808 is suggested to mediate the physiological ‘fight or flight’ response and contribute to heart failure by rendering the sarcoplasmic reticulum (SR) leaky for Ca(2+). In the present study, we examined the pot...

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Bibliografische gegevens
Gepubliceerd in:J Physiol
Hoofdauteurs: Liu, Bin, Ho, Hsiang-Ting, Velez-Cortes, Florencia, Lou, Qing, Valdivia, Carmen R, Knollmann, Bjorn C, Valdivia, Hector H, Gyorke, Sandor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2014
Onderwerpen:
Cardiovascular
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230772/
https://ncbi.nlm.nih.gov/pubmed/24445321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.264689
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