Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-type Gastric Adenocarcinoma and Metastasis

Loss of E-cadherin (CDH1), Smad4 and p53 have all been shown to play an integral role in gastric, intestinal and breast cancer formation. Compound conditional knockout mice for Smad4, p53, and E-cadherin were generated to define and compare the roles of these genes in gastric, intestinal and breast...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Park, Jun Won, Jang, Seok Hoon, Park, Dong Min, Lim, Na Jung, Deng, Chuxia, Kim, Dae Yong, Green, Jeffrey E., Kim, Hark Kyun
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230498/
https://ncbi.nlm.nih.gov/pubmed/24784840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0192-T
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