Phosphodiesterase-5 Inhibitor, Tadalafil, Protects against Myocardial Ischemia/Reperfusion through Protein-Kinase G Dependent Generation of Hydrogen Sulfide

BACKGROUND: Tadalafil is a novel long acting inhibitor of phosphodiesterase-5. Since cGMP-dependent protein kinase (PKG) signaling plays a key role in cardioprotection, we hypothesized that PKG activation with tadalafil would limit myocardial ischemia/reperfusion (I/R) injury and dysfunction. Additi...

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Bibliographic Details
Published in:Circulation
Main Authors: Salloum, Fadi N., Chau, Vinh Q., Hoke, Nicholas N., Abbate, Antonio, Varma, Amit, Ockaili, Ramzi A., Toldo, Stefano, Kukreja, Rakesh C.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230451/
https://ncbi.nlm.nih.gov/pubmed/19752383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.843979
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