Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease

Triggering receptor expressed on myeloid cells 2 (TREM2) gene is a recently identified susceptibility gene for Alzheimer's disease (AD), as its low-frequency variants increase the risk of this disease with an odds ratio similar to that of an APOE ɛ4 allele. To date, the expression and biologic...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Jiang, Teng, Tan, Lan, Zhu, Xi-Chen, Zhang, Qiao-Quan, Cao, Lei, Tan, Meng-Shan, Gu, Li-Ze, Wang, Hui-Fu, Ding, Zheng-Zheng, Zhang, Ying-Dong, Yu, Jin-Tai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229581/
https://ncbi.nlm.nih.gov/pubmed/25047746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.164
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