Investigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: Phase 1 dose-escalation study

BACKGROUND: This phase 1b study evaluated an enteric-coated tablet (ECT) formulation of the investigational Aurora A kinase inhibitor, alisertib (MLN8237). METHODS: Patients with advanced, non-hematologic malignancies received oral alisertib ECT for 7 days BID followed by 14 days treatment-free (21-...

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Bibliografiske detaljer
Udgivet i:Invest New Drugs
Main Authors: Falchook, Gerald, Kurzrock, Razelle, Gouw, Launce, Hong, David, McGregor, Kimberly A., Zhou, Xiaofei, Shi, Hongliang, Fingert, Howard, Sharma, Sunil
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229392/
https://ncbi.nlm.nih.gov/pubmed/24879333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0121-6
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