Epidermal Growth Factor Receptor Inhibition with Erlotinib Partially Prevents Cisplatin-Induced Nephrotoxicity in Rats

The effects of blocking the epidermal growth factor receptor (EGFR) in acute kidney injury (AKI) are controversial. Here we investigated the renoprotective effect of erlotinib, a selective tyrosine kinase inhibitor that can block EGFR activity, on cisplatin (CP)-induced AKI. Groups of animals were g...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wada, Yukihiro, Iyoda, Masayuki, Matsumoto, Kei, Shindo-Hirai, Yuki, Kuno, Yoshihiro, Yamamoto, Yasutaka, Suzuki, Taihei, Saito, Tomohiro, Iseri, Ken, Shibata, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229108/
https://ncbi.nlm.nih.gov/pubmed/25390346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111728
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