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Repair of a DNA-protein crosslink by replication-coupled proteolysis
DNA-protein crosslinks (DPCs) are caused by environmental, endogenous, and chemotherapeutic agents and pose a severe threat to genome stability. We use Xenopus egg extracts to recapitulate DPC repair and show that this process is coupled to DNA replication. A DPC on the leading strand template arres...
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| Publié dans: | Cell |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4229047/ https://ncbi.nlm.nih.gov/pubmed/25303529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.024 |
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