Repair of a DNA-protein crosslink by replication-coupled proteolysis

DNA-protein crosslinks (DPCs) are caused by environmental, endogenous, and chemotherapeutic agents and pose a severe threat to genome stability. We use Xenopus egg extracts to recapitulate DPC repair and show that this process is coupled to DNA replication. A DPC on the leading strand template arres...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Duxin, Julien P., Dewar, James M., Yardimci, Hasan, Walter, Johannes C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229047/
https://ncbi.nlm.nih.gov/pubmed/25303529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.024
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