SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation

Retinoid homeostasis is critical for normal embryonic development. Both the deficiency and excess of these compounds are associated with congenital malformations. Here we demonstrate that SIRT1, the most conserved mammalian NAD(+)-dependent protein deacetylase, contributes to homeostatic retinoic ac...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Tang, Shuang, Huang, Gang, Fan, Wei, Chen, Yue, Ward, James M., Xu, Xiaojiang, Xu, Qing, Kang, Ashley, McBurney, Michael W., Fargo, David C., Hu, Guang, Baumgart-Vogt, Eveline, Zhao, Yingming, Li, Xiaoling
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228935/
https://ncbi.nlm.nih.gov/pubmed/25155613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.07.011
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