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Flow Shear Stress Stimulates Gab1 Tyrosine Phosphorylation to Mediate Protein Kinase B and Endothelial Nitric-oxide Synthase Activation in Endothelial Cells()

Fluid shear stress generated by blood flow modulates endothelial cell function via specific intracellular signaling events. We showed previously that flow activated the phosphatidylinositol 3-kinase (PI3K), Akt, and endothelial nitric-oxide synthase (eNOS) via Src kinase-dependent transactivation of...

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Pubblicato in:J Biol Chem
Autori principali: Jin, Zheng-Gen, Wong, Chelsea, Wu, Jie, Berk, Bradford C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228934/
https://ncbi.nlm.nih.gov/pubmed/15665327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M500294200
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