PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner

This study was aimed to determine the role and regulation of progranulin (PGRN) in the pathogenesis of inflammatory bowel diseases (IBD). Dextran sulfate sodium (DSS)−, picrylsulfonic acid (TNBS)-induced, bone marrow chimera and CD4+CD45Rb(hi) T cell transfer colitis model were established and analy...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wei, Fanhua, Zhang, Yuying, Jian, Jinlong, Mundra, Jyoti Joshi, Tian, Qingyun, Lin, Jiqiang, Lafaille, Juan Jose, Tang, Wei, Zhao, Weiming, Yu, Xiuping, Liu, Chuan-Ju
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228332/
https://ncbi.nlm.nih.gov/pubmed/25387791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07023
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