Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

Protein kinases have evolved diverse specificities to enable cellular information processing. To gain insight into the mechanisms underlying kinase diversification, we studied the CMGC protein kinases using ancestral reconstruction. Within this group, the cyclin dependent kinases (CDKs) and mitogen...

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Veröffentlicht in:eLife
Hauptverfasser: Howard, Conor J, Hanson-Smith, Victor, Kennedy, Kristopher J, Miller, Chad J, Lou, Hua Jane, Johnson, Alexander D, Turk, Benjamin E, Holt, Liam J
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2014
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228266/
https://ncbi.nlm.nih.gov/pubmed/25310241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04126
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