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Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1
G protein-coupled receptors (GPCRs) are the major transducers of external stimuli and key therapeutic targets in many pathological conditions. When activated by different ligands, one receptor can elicit multiple signalling cascades that are mediated by G proteins or β-arrestin, a process defined as...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Pub. Group
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4227836/ https://ncbi.nlm.nih.gov/pubmed/25081814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5589 |
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