Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes

The synthesis of adequate amounts of ribosomes is an essential task for the cell. It is therefore not surprising that regulatory circuits exist to organize the synthesis of ribosomal components. It has been shown that defect in ribosome biogenesis (ribosomal stress) induces apoptosis or cell cycle a...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Gismondi, Angelo, Caldarola, Sara, Lisi, Gaia, Juli, Giada, Chellini, Lidia, Iadevaia, Valentina, Proud, Christopher G., Loreni, Fabrizio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2014
Onderwerpen:
Molecular Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227798/
https://ncbi.nlm.nih.gov/pubmed/25332393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku996
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