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Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes

The synthesis of adequate amounts of ribosomes is an essential task for the cell. It is therefore not surprising that regulatory circuits exist to organize the synthesis of ribosomal components. It has been shown that defect in ribosome biogenesis (ribosomal stress) induces apoptosis or cell cycle a...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Gismondi, Angelo, Caldarola, Sara, Lisi, Gaia, Juli, Giada, Chellini, Lidia, Iadevaia, Valentina, Proud, Christopher G., Loreni, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227798/
https://ncbi.nlm.nih.gov/pubmed/25332393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku996
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