New tools provide a second look at HDV ribozyme structure, dynamics and cleavage

The hepatitis delta virus (HDV) ribozyme is a self-cleaving RNA enzyme essential for processing viral transcripts during rolling circle viral replication. The first crystal structure of the cleaved ribozyme was solved in 1998, followed by structures of uncleaved, mutant-inhibited and ion-complexed f...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Kapral, Gary J., Jain, Swati, Noeske, Jonas, Doudna, Jennifer A., Richardson, David C., Richardson, Jane S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227795/
https://ncbi.nlm.nih.gov/pubmed/25326328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku992
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