Peptides Displayed as High Density Brush Polymers Resist Proteolysis and Retain Bioactivity

[Image: see text] We describe a strategy for rendering peptides resistant to proteolysis by formulating them as high-density brush polymers. The utility of this approach is demonstrated by polymerizing well-established cell-penetrating peptides (CPPs) and showing that the resulting polymers are not...

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Библиографические подробности
Опубликовано в: :J Am Chem Soc
Главные авторы: Blum, Angela P., Kammeyer, Jacquelin K., Yin, Jian, Crystal, Dustin T., Rush, Anthony M., Gilson, Michael K., Gianneschi, Nathan C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227725/
https://ncbi.nlm.nih.gov/pubmed/25314576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5088216
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