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Peptides Displayed as High Density Brush Polymers Resist Proteolysis and Retain Bioactivity
[Image: see text] We describe a strategy for rendering peptides resistant to proteolysis by formulating them as high-density brush polymers. The utility of this approach is demonstrated by polymerizing well-established cell-penetrating peptides (CPPs) and showing that the resulting polymers are not...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4227725/ https://ncbi.nlm.nih.gov/pubmed/25314576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5088216 |
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