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Synthesis and Late-Stage Functionalization of Complex Molecules through C–H Fluorination and Nucleophilic Aromatic Substitution

[Image: see text] We report the late-stage functionalization of multisubstituted pyridines and diazines at the position α to nitrogen. By this process, a series of functional groups and substituents bound to the ring through nitrogen, oxygen, sulfur, or carbon are installed. This functionalization i...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Fier, Patrick S., Hartwig, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227713/
https://ncbi.nlm.nih.gov/pubmed/24918484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5049303
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