Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

BACKGROUND: High-throughput measurement technologies such as microarrays provide complex datasets reflecting mechanisms perturbed in an experiment, typically a treatment vs. control design. Analysis of these information rich data can be guided based on a priori knowledge, such as networks or set of...

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Vydáno v:BMC Bioinformatics
Hlavní autoři: Martin, Florian, Sewer, Alain, Talikka, Marja, Xiang, Yang, Hoeng, Julia, Peitsch, Manuel C
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227138/
https://ncbi.nlm.nih.gov/pubmed/25015298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-15-238
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